" Worldwide in 2016, more than half (57%, or 3.1 billion people) of the global population aged 15 years and over had abstained from drinking alcohol in the previous 12 months. Some 2.3 billion people are current drinkers. Alcohol is consumed by more than half of the population in only three WHO regions – the Americas, Europe and Western Pacific.
"Nationwide, 29.8% of students had had at least one drink of alcohol on at least 1 day during the 30 days before the survey (i.e., current alcohol use) (Supplementary Table 98). The prevalence of current alcohol use was higher among female (31.8%) than male (27.6%) students; higher among black female (24.3%) and Hispanic female (35.9%) than black male (16.9%) and Hispanic male (26.8%) students, respectively; and higher among 9th-grade female (22.0%) and 11th-grade female (36.8%) than 9th-grade male (15.3%) and 11th-grade male (31.6%) students, respectively.
"We generally found significant associations between 12-month and lifetime AUD and other substance use disorders, major depressive disorder, bipolar I disorder, specific phobia, and antisocial and borderline PDs when we controlled for sociodemographic characteristics and other disorders. Significant associations between persistent depressive disorder, posttraumatic stress disorder, panic disorder, and generalized anxiety disorder with lifetime AUD were also observed.
"Consistent with previous research, rates of AUD [Alcohol Use Disorder] were greater among men than women.1,2,5,14 Age was inversely related to 12-month AUD, a finding also observed in earlier epidemiologic studies.1-5,14 Whether this result is owing to cohort effects, differential mortality, or recall bias merits further investigation. The 12-month rate of 7.1% for severe AUD among 18- to 29-year-old respondents is especially striking.
"In 2012 through 2013, US prevalences of DSM-5 12-month and lifetime AUD [Alcohol Use Disorder] among adults 18 years and older were 13.9% and 29.1%, respectively, representing approximately 32 648 000 and 68 485 000 individuals, respectively, in the United States.
"During the 2014–15 school year, there were 22,500 reported alcohol-related discipline incidents in the United States (table 15.5).73 The number of alcohol-related incidents varies widely across jurisdictions, due in large part to their differing populations. Therefore, the rate of alcohol-related discipline incidents per 100,000 students can provide a more comparable indication of the frequency of these incidents across jurisdictions. During the 2014–15 school year, the rate of alcohol-related discipline incidents was 45 per 100,000 students in the United States.
"On average, 6 people died every day from alcohol poisoning in the US from 2010 to 2012. Alcohol poisoning is caused by drinking large quantities of alcohol in a short period of time. Very high levels of alcohol in the body can shutdown critical areas of the brain that control breathing, heart rate, and body temperature, resulting in death. Alcohol poisoning deaths affect people of all ages but are most common among middle-aged adults and men."
(Odds Of Involvement In Fatal Auto Accidents Associated With Use Of Various Substances) "The prevalence of drugs detected in cases was higher than in controls across the drug categories (Table 3). Marijuana, narcotics, stimulants, and depressants were each associated with a significantly increased risk of fatal crash involvement, with estimated odds ratios ranging from 1.83 for marijuana to 4.83 for depressants (Table 3). Polydrug use, defined as use of two or more non-alcohol drugs, was associated with a 3.4-fold increased risk of fatal crash involvement (Table 3).
(Comparison of Results from Standardized Field Sobriety Tests (SFST) and Roadside Saliva Drug Tests in Detecting Cannabis Use) "The SFST was mildly sensitive to the effects of cannabis alone. A dose of 400 ?g/kg body weight THC significantly increased the percentage of participants displaying impairments in OLS compared to baseline performance from 21 to 50 %. THC also increased percentage of individuals showing impairment on HGN from 0 to 15 %, relative to baseline, but this change only approached statistical significance.
(Comparison of Results from Standardized Field Sobriety Tests (SFST) and Roadside Drug Testing)
"Methods Twenty heavy cannabis users (15 males and 5 females; mean age, 24.3 years) participated in a double-blind, placebo-controlled study assessing percentage of impaired individuals on the SFST and the sensitivity of two oral fluid devices. Participants received alcohol doses or
alcohol placebo in combination with 400 ?g/kg body weight THC. We aimed to reach peak blood alcohol concentration values of 0.5 and 0.7 mg/mL.