Ibogaine is an extract from the iboga plant, native to Africa. For the past few decades there has been growing interest in its use in therapy for substance use disorders.

Ibogaine Subculture Contrasted With Other Drug Subcultures

"The clinical focus on the treatment of opioid withdrawal distinguishes the ibogaine subculture from subcultures associated with psychedelic or other illegal drugs. The reason for taking ibogaine was more frequently to alleviate the symptoms of opioid withdrawal than to pursue spiritual or psychological goals. In the US, the expansion of the ibogaine subculture coincides temporally with a substantial increase in the public health impact of opioid use disorders (Compton and Volkow, 2006).

Ibogaine Treatment Outside the United States

"The medical treatment model presently exists mainly in countries adjacent to the US, such as Mexico, where ibogaine is subsumed within a physician’s legal prerogative to prescribe experimental treatment, or Saint Kitts, where the government includes ibogaine in its national formulary and provides specific approval to the clinic there to administer it. The most common setting is a private clinic with less frequent use of hospitals."

How Ibogaine Works as a Treatment for Addiction or Substance Use Disorder

How Ibogaine Works as a Treatment for Addiction or Substance Use Disorder: "As these researchers point out, and those most familiar with the treatment will testify, ibogaine is not, in general, a 'cure' for drug addiction.122 In the majority of cases, however, it does eliminate or substantially decrease signs and symptoms of withdrawal and the individual typically emerges some 36 hours later without physical dependence on the drug.123 'Ibogaine doesn’t eradicate the underlying causes of addiction, which for many people may take years to unders

History Of Ibogaine As Treatment For Substance Use Disorder In The US

"In 1962, the anti-addictive property of ibogaine was inadvertently discovered by 19-year-old heroin addict Howard Lotsof.58 Lotsof was part of an experimental group of mostly 20-something Caucasians attending college.59 The group, which included seven heroin addicts, shared a common interest in experimenting and subjectively evaluating their experiences with various psychoactive drugs, including Mescaline, LSD, DMT, and psilocybin,60 in an effort to determine the psychotherapeutic value of hallucinogenic drugs.61 As psychedelic drugs were not ill

Physical and Psychological Effects of Ibogaine in the Context of Addiction (Substance Use Disorder) Treatment

"Within three hours after ingesting a higher dose of ibogaine, the user will enter into the 'acute phase,' typically lasting four to eight hours.42 It is during this phase that the user experiences ibogaine’s most intense effects, characterized as the 'panoramic recall of a large amount of material relating to prior life events from long-term memory, primarily in the visual modality,' or the 'waking dream' state.43 If the user is an addict, he or she will usually be taken back to the place and time where the underlying issue leading t

Rat Studies of Ibogaine

"18-MC [18-methoxycoronaridine], a novel iboga alkaloid congener, reduces intravenous methamphetamine and nicotine self-administration in rats. These and previous results with morphine, cocaine and alcohol indicate that 18-MC warrants further development as a potential treatment for multiple forms of drug addiction."

Reported Effects of Ibogaine and Effectiveness in Treatment for Substance Use Disorders

"Ibogaine, a natural alkaloid extracted from the root bark of the African shrub Tabernanthe Iboga, has attracted attention because of its reported ability to reverse human addiction to multiple drugs of abuse, including alcohol. Human anecdotal reports assert that a single administration of ibogaine reduces craving for opiates and cocaine for extended periods of time and reduces opiate withdrawal symptoms (Sheppard 1994; Mash et al., 1998; Alper et al., 1999). Studies also suggest that ibogaine attenuates drug- and ethanol induced behaviors in rodents.