Annual Number of Deaths By Selected Causes in the US, Including Deaths Attributed to Alcohol, Tobacco, and Other Drug Use

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Cause of death (Data from 2016 unless otherwise noted) Number All Causes 2,744,248 Major Cardiovascular Diseases [MCD] 835,947    Diseases of Heart [subset of MCD]    635,260    Cerebrovascular Diseases [subset of MCD]    142,142 Malignant Neoplasms [Cancer] 598,038 Deaths Attributed to Tobacco Smoking (Each year from 2005 through 2009)1 480,320 Accidents (Unintentional Injuries) [Total] 161,374    Motor Vehicle Accidents [subset of Total Accidents]    40,327 Chronic Lower Respiratory Diseases 154,596 Alzheimer's Disease 116,103 Diabetes Mellitus 80,058 Drug-Induced Deaths2 67,265 Influenza and Pneumonia 51,537 Nephritis, Nephrotic Syndrome and Nephrosis 50,046 Intentional Self-Harm (Suicide) 44,965 Septicemia 40,613 Chronic Liver Disease and Cirrhosis 40,545    Alcoholic Liver Disease [subset of Chronic Liver Disease]    21,815 Injury by Firearms 38,658 Alcohol-Induced Deaths 34,865 Parkinson's Disease 29,697 Pneumonitis Due to Solids and Liquids 19,715 Assault (Homicide) 19,362 Viral Hepatitis 6,421 Human Immunodeficiency Virus (HIV) Disease 6,160 All Illicit Drugs Combined (2000)3 17,0002 Cannabis (Marijuana)4 0 2016 Data Detailing Drug-Induced Deaths, Breaking Out Specific Data for Natural and Semi-Synthetic Opioids (including Oxycodone), Synthetic Opioids (including Fentanyl), and Heroin, as Reported by the CDC7 Total Deaths Attributed to Drug Overdose 63,632 Overdose Deaths Involving Any Opioid 42,249 Overdose Deaths Involving Heroin 15,469 Overdose Deaths Involving Natural and Semi-Synthetic Opioids 14,487 Overdose Deaths Involving Methadone 3,373 Overdose Deaths Involving Synthetic Opioids Other Than Methadone 19,413 2014 Data Detailing Drug-Induced Deaths, Breaking Out Specific Data for Prescription Analgesics and Heroin, as Reported by the CDC5 Drug Overdose Total 47,055 Deaths Involving Pharmaceutical Opioid Analgesics 18,893 Deaths Involving Heroin 10,574 2010 Drug Overdose Mortality Data In Detail, Reported By Paulozzi et al." data-share-imageurl="">


Cause of death (Data from 2016 unless otherwise noted) Number
All Causes 2,744,248
Major Cardiovascular Diseases [MCD] 835,947
   Diseases of Heart [subset of MCD]    635,260
   Cerebrovascular Diseases [subset of MCD]    142,142
Malignant Neoplasms [Cancer] 598,038
Deaths Attributed to Tobacco Smoking (Each year from 2005 through 2009)1 480,320
Accidents (Unintentional Injuries) [Total] 161,374
   Motor Vehicle Accidents [subset of Total Accidents]    40,327
Chronic Lower Respiratory Diseases 154,596
Alzheimer's Disease 116,103
Diabetes Mellitus 80,058
Drug-Induced Deaths2 67,265
Influenza and Pneumonia 51,537
Nephritis, Nephrotic Syndrome and Nephrosis 50,046
Intentional Self-Harm (Suicide) 44,965
Septicemia 40,613
Chronic Liver Disease and Cirrhosis 40,545
   Alcoholic Liver Disease [subset of Chronic Liver Disease]    21,815
Injury by Firearms 38,658
Alcohol-Induced Deaths 34,865
Parkinson's Disease 29,697
Pneumonitis Due to Solids and Liquids 19,715
Assault (Homicide) 19,362
Viral Hepatitis 6,421
Human Immunodeficiency Virus (HIV) Disease 6,160
All Illicit Drugs Combined (2000)3 17,0002
Cannabis (Marijuana)4 0

2016 Data Detailing Drug-Induced Deaths,
Breaking Out Specific Data for Natural and Semi-Synthetic Opioids (including Oxycodone), Synthetic Opioids (including Fentanyl), and Heroin,
as Reported by the CDC7
Total Deaths Attributed to Drug Overdose 63,632
Overdose Deaths Involving Any Opioid 42,249
Overdose Deaths Involving Heroin 15,469
Overdose Deaths Involving Natural and Semi-Synthetic Opioids 14,487
Overdose Deaths Involving Methadone 3,373
Overdose Deaths Involving Synthetic Opioids Other Than Methadone 19,413

2014 Data Detailing Drug-Induced Deaths,
Breaking Out Specific Data for Prescription Analgesics and Heroin,
as Reported by the CDC5
Drug Overdose Total 47,055
Deaths Involving Pharmaceutical Opioid Analgesics 18,893
Deaths Involving Heroin 10,574

2010 Drug Overdose Mortality Data In Detail,
Reported By Paulozzi et al.6
Drug Overdose Total 38,329
Deaths Involving Pharmaceutical Drugs 22,134
Deaths Involving Pharmaceutical Opioids 16,651

1 Estimated number of deaths annually 2005-2009. U.S. Department of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.
2 "Drug" includes both legal and illegal drugs.

3 Mokdad, Ali H., PhD, James S. Marks, MD, MPH, Donna F. Stroup, PhD, MSc, Julie L. Gerberding, MD, MPH, "Actual Causes of Death in the United States, 2000," Journal of the American Medical Association, (March 10, 2004), G225 Vol. 291, No. 10, 1242.

4 No recorded cases of overdose deaths from cannabis have been found in extensive literature reviews, see for example Gable, Robert S., "The Toxicity of Recreational Drugs," American Scientist (Research Triangle Park, NC: Sigma Xi, The Scientific Research Society, May-June 2006) Vol. 94, No. 3, p. 207.

5 CDC/NCHS, National Vital Statistics System, Mortality File, 2015, last accessed Dec. 11, 2015.

6 Paulozzi et al analyzed mortality figures and found that of 38,329 drug overdose deaths then reported in 2010, pharmaceutical drugs accounted for 22,134 deaths, of which 16,651 were opiod analgesic overdoses. The data were apparently revised slightly between the time the research letter was published in JAMA (February 2013) and release of the CDC's Deaths: Final Data for 2010 publication report, officially dated May 8, 2013.
7 Hedegaard H, Warner M, Miniño AM. Drug overdose deaths in the United States, 1999–2016. NCHS Data Brief, no 294. Hyattsville, MD: National Center for Health Statistics. 2017.

Source: 

Xu JQ, Murphy SL, Kochanek KD, Bastian B, Arias E. Deaths: Final data for 2016. National Vital Statistics Reports; vol 67 no 5. Hyattsville, MD: National Center for Health Statistics. 2018.
https://www.cdc.gov/nchs/nvss/...
https://www.cdc.gov/nchs/data/...
Hedegaard H, Warner M, Miniño AM. Drug overdose deaths in the United States, 1999–2016. NCHS Data Brief, no 294. Hyattsville, MD: National Center for Health Statistics. 2017.
https://www.cdc.gov/nchs/produ...
https://www.cdc.gov/nchs/data/...
https://www.cdc.gov/nchs/data/...
CDC/NCHS, National Vital Statistics System, Mortality File, 2015, last accessed Dec. 11, 2015.
http://www.cdc.gov/nchs/data/h...
Hedegaard H, Chen LH, Warner M. Drug poisoning deaths involving heroin: United States, 2000–2013. NCHS data brief, no 190. Hyattsville, MD: National Center for Health Statistics. 2015.
http://www.cdc.gov/nchs/data/d...
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Chen LH, Hedegaard H, Warner M. Drug-poisoning deaths involving opioid analgesics: United States, 1999–2011. NCHS data brief no. 166.
Hyattsville, MD: US Department of Health and Human Services, CDC; 2014, p. 1.
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http://www.cdc.gov/nchs/data/h...
Christopher M. Jones, PharmD, Karin A. Mack, PhD, and Leonard J. Paulozzi, MD, "Pharmaceutical Overdose Deaths, United States, 2010," Journal of the American Medical Association, February 20, 2013, Vol 309, No. 7, p. 658.
http://jama.jamanetwork.com/ar...
U.S. Department of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014. Printed with corrections, January 2014, p. 660, Table 12.4
https://www.surgeongeneral.gov...
https://www.surgeongeneral.gov...

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Cause of death (Data from 2016 unless otherwise noted) Number All Causes 2,744,248 Major Cardiovascular Diseases [MCD] 835,947    Diseases of Heart [subset of MCD]    635,260    Cerebrovascular Diseases [subset of MCD]    142,142 Malignant Neoplasms [Cancer] 598,038 Deaths Attributed to Tobacco Smoking (Each year from 2005 through 2009)1 480,320 Accidents (Unintentional Injuries) [Total] 161,374    Motor Vehicle Accidents [subset of Total Accidents]    40,327 Chronic Lower Respiratory Diseases 154,596 Alzheimer's Disease 116,103 Diabetes Mellitus 80,058 Drug-Induced Deaths2 67,265 Influenza and Pneumonia 51,537 Nephritis, Nephrotic Syndrome and Nephrosis 50,046 Intentional Self-Harm (Suicide) 44,965 Septicemia 40,613 Chronic Liver Disease and Cirrhosis 40,545    Alcoholic Liver Disease [subset of Chronic Liver Disease]    21,815 Injury by Firearms 38,658 Alcohol-Induced Deaths 34,865 Parkinson's Disease 29,697 Pneumonitis Due to Solids and Liquids 19,715 Assault (Homicide) 19,362 Viral Hepatitis 6,421 Human Immunodeficiency Virus (HIV) Disease 6,160 All Illicit Drugs Combined (2000)3 17,0002 Cannabis (Marijuana)4 0 2016 Data Detailing Drug-Induced Deaths, Breaking Out Specific Data for Natural and Semi-Synthetic Opioids (including Oxycodone), Synthetic Opioids (including Fentanyl), and Heroin, as Reported by the CDC7 Total Deaths Attributed to Drug Overdose 63,632 Overdose Deaths Involving Any Opioid 42,249 Overdose Deaths Involving Heroin 15,469 Overdose Deaths Involving Natural and Semi-Synthetic Opioids 14,487 Overdose Deaths Involving Methadone 3,373 Overdose Deaths Involving Synthetic Opioids Other Than Methadone 19,413 2014 Data Detailing Drug-Induced Deaths, Breaking Out Specific Data for Prescription Analgesics and Heroin, as Reported by the CDC5 Drug Overdose Total 47,055 Deaths Involving Pharmaceutical Opioid Analgesics 18,893 Deaths Involving Heroin 10,574 2010 Drug Overdose Mortality Data In Detail, Reported By Paulozzi et al." data-share-imageurl="">