Entheogens and Psychedelics including Ayahuasca, LSD, Peyote, Mescaline, Psilocybin Mushrooms, Salvia

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Related Chapter:
Ibogaine

Page last updated June 9, 2020 by Doug McVay, Editor/Senior Policy Analyst.

26. How To Use Psilocybin (Magic Mushrooms)

"Mushrooms containing psilocybin are available fresh or dried and are typically taken orally. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and its biologically active form, psilocin (4-hydroxy-N,N-dimethyltryptamine), cannot be inactivated by cooking or freezing preparations. Thus, they may also be brewed as a tea or added to other foods to mask their bitter flavor. The effects of psilocybin, which appear within 20 minutes of ingestion, last approximately 6 hours."

NIDA InfoFacts, "Hallucinogens: LSD, Peyote, Psilocybin, and PCP" National Institute on Drug Abuse (Bethesda, MD: National Institutes of Health, June 2009)
http://www.drugabuse.gov/sites...

27. Physical Effects of Psilocybin

"[Psilocybin] can produce muscle relaxation or weakness, ataxia, excessive pupil dilation, nausea, vomiting, and drowsiness. Individuals who abuse psilocybin mushrooms also risk poisoning if one of many existing varieties of poisonous mushrooms is incorrectly identified as a psilocybin mushroom."

NIDA InfoFacts, "Hallucinogens: LSD, Peyote, Psilocybin, and PCP" National Institute on Drug Abuse (Bethesda, MD: National Institutes of Health, June 2009)
http://www.drugabuse.gov/sites...

28. Effects of Psilocybin

"The active compounds in psilocybin-containing 'magic' mushrooms have LSD-like properties and produce alterations of autonomic function, motor reflexes, behavior, and perception.3 The psychological consequences of psilocybin use include hallucinations, an altered perception of time, and an inability to discern fantasy from reality. Panic reactions and psychosis also may occur, particularly if a user ingests a large dose. Long-term effects such as flashbacks, risk of psychiatric illness, impaired memory, and tolerance have been described in case reports."

NIDA InfoFacts, "Hallucinogens: LSD, Peyote, Psilocybin, and PCP" National Institute on Drug Abuse (Bethesda, MD: National Institutes of Health, June 2009)
http://www.drugabuse.gov/sites...

29. Psilocybin and Mystical Experiences

"Overall, the present study shows that psilocybin can dose-dependently occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. The observations that episodes of extreme fear, feeling trapped, or delusions occur at the highest dose in almost 40% of volunteers, that anxiety and fear have an unpredictable time course across the session, and that an ascending sequence of dose exposure may be associated with long-lasting positive changes have implications for the design of therapeutic trials with psilocybin. Considering the rarity of spontaneous mystical experiences in the general population, the finding that more than 70% of volunteers in the current study had 'complete' mystical experiences suggests that most people have the capacity for such experiences under appropriate conditions and, therefore, such experiences are biologically normal."

Griffiths, Roland R.; Johnson, Matthew W.; Richards, William A.; Richards, Brian D.; McCann, Una; and Jesse, Robert, "Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects," Psychopharmacology (Heidelberg, Germany: May 2011), p. 16.
http://link.springer.com/artic...

30. Safety of Psilocybin in Clinical Setting

"Our investigations provided no cause for concern that administration of PY [psilocybin] to healthy subjects is hazardous with respect to somatic health. However, as our data revealed tendencies of PY to temporarily increase blood pressure, we advise subjects suffering from cardiovascular conditions, especially untreated hypertension, to abstain from using PY or PY-containing mushrooms. Furthermore, our results indicate that PY-induced ASC [altered states of consciousness] are generally well tolerated and integrated by healthy subjects. However, a controlled clinical setting is needful, since also mentally stable personalities may, following ingestion of higher doses of PY, transiently experience anxiety as a consequence of loosening of ego-boundaries."

Hasler, Felix; Grimberg, Ulrike; Benz , Marco A.; Huber, Theo; and Vollenweider, Franz, "Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study," Psychopharmacology (Heidelberg, Germany: March 2004) Volume 172, Number 2, p. 151.
http://www.beckleyfoundation.o...

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