United States

Treatment with Methadone or Buprenorphine Following Nonfatal Overdose Leads to Decreased Mortality

"In the 12 months after a nonfatal overdose, 2040 persons (11%) enrolled in MMT for a median of 5 months (interquartile range, 2 to 9 months), 3022 persons (17%) received buprenorphine for a median of 4 months (interquartile range, 2 to 8 months), and 1099 persons (6%) received naltrexone for a median of 1 month (interquartile range, 1 to 2 months). Among the entire cohort, all-cause mortality was 4.7 deaths (95% CI, 4.4 to 5.0 deaths) per 100 person-years and opioid-related mortality was 2.1 deaths (CI, 1.9 to 2.4 deaths) per 100 person-years.

Mental Health Medications: Anti-Anxiety Medications

"Anti-anxiety medications help reduce the symptoms of anxiety, such as panic attacks, or extreme fear and worry. The most common anti-anxiety medications are called benzodiazepines. Benzodiazepines can treat generalized anxiety disorder. In the case of panic disorder or social phobia (social anxiety disorder), benzodiazepines are usually second-line treatments, behind SSRIs or other antidepressants.

"Benzodiazepines used to treat anxiety disorders include:
"Clonazepam
"Alprazolam
"Lorazepam

Antidepressant Side Effects

"The most common side effects listed by the FDA include:

"Nausea and vomiting
"Weight gain
"Diarrhea
"Sleepiness
"Sexual problems

"Call your doctor right away if you have any of the following symptoms, especially if they are new, worsening, or worry you(U.S. Food and Drug Administration, 2011):

Mental Health Medications: Antidepressants

"Antidepressants are medications commonly used to treat depression. Antidepressants are also used for other health conditions, such as anxiety, pain and insomnia. Although antidepressants are not FDA-approved specifically to treat ADHD, antidepressants are sometimes used to treat ADHD in adults.

"The most popular types of antidepressants are called selective serotonin reuptake inhibitors (SSRIs). Examples of SSRIs include:

Tighter Prescribing Regulations Drive Illegal Sales

"The US Drug Enforcement Administration introduced a schedule change for hydrocodone combination products in October 2014. During the period of our study, October 2013 to July 2016, the percentage of total drug sales represented by prescription opioids in the US doubled from 6.7% to 13.7%, which corresponds to a yearly increase of 4 percentage points in market share. It is not possible to determine the location of buyers from cryptomarket data. We cannot know, for example, if a drug shipped from a vendor in Europe was purchased by a US customer.

Receipt of Services among Adults in the US with Co-Occurring Serious Mental Illness and a Substance Use Disorder

"Among the 2.6 million adults who had co‑occurring SMI [Serious Mental Illness] and an SUD [Substance Use Disorder] in the past year, 65.6 percent received either substance use treatment at a specialty facility or mental health care in the past year (Figure 31). Stated another way, about 1 in 3 adults with co‑occurring SMI and an SUD did not receive either type of care in the past year.

Receipt of Services among Adults in the US with Co-Occurring Mental Illness and a Substance Use Disorder

"An estimated 8.2 million adults aged 18 or older in 2016 had co‑occurring AMI [Any Mental Illness] and an SUD [Substance Use Disorder] in the past year, corresponding to 3.4 percent of all adults. In addition, about 2.6 million adults had SMI and an SUD in the past year, representing 1.1 percent of all adults.1

Post-Traumatic Stress Disorder (PTSD) and Lifetime DSM-5 Psychiatric Disorders among Veterans

"In this study, the highest levels of comorbidity (six or more comorbid conditions) among veterans were observed among treatment seekers. However, only those with comorbid DUD [Drug Use Disorders] were significantly more likely to seek treatment for PTSD once potentially confounding factors were accounted for. It is of concern that, in the present sample, 32% of veterans with PTSD who did not seek treatment had 6+ comorbid conditions.

Association Between Post-Traumatic Stress Disorder (PTSD) and Lifetime DSM-5 Psychiatric Disorders among Veterans

"Overall, the prevalence of 6.3% for lifetime DSM-5 PTSD in U.S. veterans is lower than that reported in previous studies of era-specific (18.7% and 52%) (Dohrenwend et al., 2007; Ikin et al., 2010; Jakupcak et al., 2010) veteran cohorts but similar to a national sample of veterans (7.95%; Wisco et al., 2014) using previous diagnostic classifications. In part this may reflect the narrow definition used in the study. However, the lifetime prevalence of PTSD among veterans in this study was very similar to the prevalences of 6.4% and 7.8% reported for DSM-IV PTSD in the general U.S.

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