Rodent Studies of Ibogaine and Clinical Safety

"Based on anecdotal reports in humans, ibogaine has been claimed [1] to be effective in interrupting dependence on opioids, stimulants, alcohol and nicotine. Preclinical studies in rats have supported these claims: ibogaine has been reported to decrease the i.v. self-administration of morphine [2] and cocaine [3] and the oral intake of alcohol [4] and nicotine [5]. However, studies in rats have also raised concerns regarding potential adverse effects of ibogaine; most notably, high doses have been shown to be neurotoxic to the cerebellum [6,7]."


Glick, S.D., Maisonneuve, I.M., and Dickinson, H.A., "18-MC Reduces Methamphetamine and Nicotine Self-Administration in Rats," Neuropharmacology, Vol. 11, No. 9, June 26, 2000, p. 2013.