Reported Effects of Ibogaine and Effectiveness in Treatment for Substance Use Disorders
"Ibogaine, a natural alkaloid extracted from the root bark of the African shrub Tabernanthe Iboga, has attracted attention because of its reported ability to reverse human addiction to multiple drugs of abuse, including alcohol. Human anecdotal reports assert that a single administration of ibogaine reduces craving for opiates and cocaine for extended periods of time and reduces opiate withdrawal symptoms (Sheppard 1994; Mash et al., 1998; Alper et al., 1999). Studies also suggest that ibogaine attenuates drug- and ethanol induced behaviors in rodents. For example, ibogaine reduces operant self-administration of heroin in rats, as well as naloxone precipitated withdrawal in morphine-dependent rats (Glick et al., 1992; Dworkin et al., 1995). Administration of ibogaine decreases cocaine-induced locomotor activity and reduces cocaine self-administration in rats (Cappendijk and Dzoljic, 1993) and mice (Sershen et al., 1994). Rezvani et al. (1995) reported that ibogaine reduces ethanol self-administration in alcohol-preferring selected lines of rats; however, the effects of ibogaine have not been tested in an operant procedure in which oral ethanol reinforces lever press behavior. Our first aim was to extend the characterization of the effects of ibogaine on ethanol self-administration to the operant procedure, including a test of the effects of ibogaine on reinstatement of ethanol self-administration after a period of extinction."
Dao-Yao He, Nancy N.H. McGough, Ajay Ravindranathan, Jerome Jeanblanc, Marian L. Logrip, Khanhky Phamluong, Patricia H. Janak, and Dorit Ron, "Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption," The Journal of Neuroscience, Jan. 19, 2005, Vol. 25, No. 3, p. 619.