Reported Adverse Effects of Phenethylamines
"Phenethylamines included in the ‘D series’ are described to be longer lasting, more potent and reportedly more liable to induce vasoconstriction than other members of the phenethylamine family.49 Reported adverse effects associated with the use of the ‘D series’ derivatives include agitation, tachycardia, mydriasis, hallucinations, severe limb ischemia, seizures, liver and renal failure.50 Bromo-Dragonfly has also been associated with a number of deaths in Scandinavia.51 A case of acute psychosis after ingestion of 2C-T-4 was reported in Japan.52 Three fatal cases associated with the use of 2C-T-7 have been identified, two of which involved poly-drug use.53
"PMA, PMMA and 4-methylthioamfetamine have been more often associated with incidental deaths than other phenethylamines. PMA and PMMA are known to have a particularly high toxicity but there is no data available on fatalities associated with their use. Clinical observations have reported severe hyperthermia following the use of these substances.54 Studies in animals have suggested that some metabolites may be exposed to increased toxicity from 4-MTA."
UN Office on Drugs and Crime, "The Challenge of New Psychoactive Substances: A Report from the Global SMART Programme" (Vienna, Austria: UNODC Laboratory and Scientific Section, March 2013), pp. 10-11.