(Effects of Salvia Divinorum) "Consistent with results from nonhuman animal research (Mowry et al.,2003), the present results suggest a safe physiological profile for salvinorin A at the studied doses, under controlled conditions, and in psychologically and physically healthy hallucinogen-experienced participants. Salvinorin A produced no significant changes in heart rate or blood pressure; no tremor was observed; and no adverse events were reported. Participants tolerated all doses.
Entheogens, psychedelics and substances used for spiritual development and the expansion of consciousness.
(Psilocybin and Treatment of End-Stage Cancer Anxiety) "Despite the limitations, this study demonstrates that the careful and controlled use of psilocybin may provide an alternative model for the treatment of conditions that are often minimally responsive to conventional therapies, including the profound existential anxiety and despair that often accompany advanced-stage cancers.
"Mushrooms containing psilocybin are available fresh or dried and are typically taken orally. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and its biologically active form, psilocin (4-hydroxy-N,N-dimethyltryptamine), cannot be inactivated by cooking or freezing preparations. Thus, they may also be brewed as a tea or added to other foods to mask their bitter flavor. The effects of psilocybin, which appear within 20 minutes of ingestion, last approximately 6 hours."
"Its effects can be similar to those of LSD, including increased body temperature and heart rate, uncoordinated movements (ataxia), profound sweating, and flushing. The active ingredient mescaline has also been associated, in at least one report, to fetal abnormalities."
Addictive Properties of LSD and Development of Tolerance: "Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered an addictive drug since it does not produce compulsive drug-seeking behavior. However, LSD does produce tolerance, so some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, cross-tolerance between LSD and other hallucinogens has been reported."
Ayahuasca Healing Ceremonies: "Cross-cultural vegetalismo refers to ayahuasca ceremonies based, to varying degrees, on vegetalismo or equivalent traditions from other regions of the Amazon, but conducted primarily for (and increasingly by) non-Amazonians.
"On February 21 of this year, 2006, the US Supreme Court ruled in favor of the Centro Espírita Beneficente União do Vegetal (the UDV) in the case “Alberto R. Gonzales, Attorney General, et al. Petitioners v. O Centro Espirita Beneficente União do Vegetal et al.” The UDV is now legally allowed to drink ayahuasca (which contains the controlled substance DMT) in their ceremonies here in the US."
Prevalence and Trends in LSD Use Among Young People in the US: "Past-year use of LSD, one of the major drugs in the hallucinogen class, has been hovering for about a decade at its lowest levels recorded by the study (Figure 5-4e). In 2015 the levels of use for students in 8th, 10th, and 12th grade were 0.9%, 2.0%, and 2.9%, respectively. Consistent with most other drugs, use increased during the 1990s relapse and peaked in the mid-1990s. It then subsequently declined to its lowest levels ever in the early 2000s, where it has since plateaued.
Prevalence of Use of Salvia Divinorum Among Young People in the US: "Annual prevalence of this drug has been in a steady decline, and in 2015 levels were only 0.7%, 1.2%, and 1.9% among 8th, 10th, and 12th graders, respectively."
"Ayahuasca is a psychedelic decoction made from plants native to the Amazon Basin—most often Banisteriopsis caapi and Psychotria viridis—and which contains harmala alkaloids and N,Ndimethyltryptamine (DMT), the latter being a controlled substance scheduled under the 1971 Convention on Psychotropic Substances."