Annual Number of Deaths By Selected Causes in the US, including deaths attributed to Alcohol, Tobacco, and Other Drug Use


Cause of death (Data from 2015 unless otherwise noted) Number
All Causes 2,712,630
Major Cardiovascular Diseases [MCD] 832,024
   Diseases of Heart [subset of MCD]    633,842
   Cerebrovascular Diseases [subset of MCD]    140,323
Malignant Neoplasms [Cancer] 595,930
Deaths Attributed to Tobacco Smoking (Each year from 2005 through 2009)1 480,320
Chronic Lower Respiratory Diseases 155,041
Accidents (Unintentional Injuries) [Total] 146,571
   Motor Vehicle Accidents [subset of Total Accidents]    37,757
Alzheimer's Disease 110,561
Diabetes Mellitus 79,535
Influenza and Pneumonia 57,062
Drug-Induced Deaths2 55,403
Nephritis, Nephrotic Syndrome and Nephrosis 49,959
Intentional Self-Harm (Suicide) 44,193
Septicemia 40,773
Chronic Liver Disease and Cirrhosis 40,326
   Alcoholic Liver Disease [subset of Chronic Liver Disease]    21,028
Injury by Firearms 36,252
Alcohol-Induced Deaths 33,171
Parkinson's Disease 27,972
Pneumonitis Due to Solids and Liquids 19,803
Homicide 17,793
Viral Hepatitis 7,461
Human Immunodeficiency Virus (HIV) Disease 6,465
All Illicit Drugs Combined (2000)3 17,0002
Cannabis (Marijuana)4 0

2016 Data Detailing Drug-Induced Deaths,
Breaking Out Specific Data for Natural and Semi-Synthetic Opioids (including Oxycodone), Synthetic Opioids (including Fentanyl), and Heroin,
as Reported by the CDC7
Total Deaths Attributed to Drug Overdose 63,632
Overdose Deaths Involving Any Opioid 42,249
Overdose Deaths Involving Heroin 15,469
Overdose Deaths Involving Natural and Semi-Synthetic Opioids 14,487
Overdose Deaths Involving Methadone 3,373
Overdose Deaths Involving Synthetic Opioids Other Than Methadone 19,413

2014 Data Detailing Drug-Induced Deaths,
Breaking Out Specific Data for Prescription Analgesics and Heroin,
as Reported by the CDC5
Drug Overdose Total 47,055
Deaths Involving Pharmaceutical Opioid Analgesics 18,893
Deaths Involving Heroin 10,574

2010 Drug Overdose Mortality Data In Detail,
Reported By Paulozzi et al.6
Drug Overdose Total 38,329
Deaths Involving Pharmaceutical Drugs 22,134
Deaths Involving Pharmaceutical Opioids 16,651

1 Estimated number of deaths annually 2005-2009. U.S. Department of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.
2 "Drug" includes both legal and illegal drugs.

3 Mokdad, Ali H., PhD, James S. Marks, MD, MPH, Donna F. Stroup, PhD, MSc, Julie L. Gerberding, MD, MPH, "Actual Causes of Death in the United States, 2000," Journal of the American Medical Association, (March 10, 2004), G225 Vol. 291, No. 10, 1242.

4 No recorded cases of overdose deaths from cannabis have been found in extensive literature reviews, see for example Gable, Robert S., "The Toxicity of Recreational Drugs," American Scientist (Research Triangle Park, NC: Sigma Xi, The Scientific Research Society, May-June 2006) Vol. 94, No. 3, p. 207.

5 CDC/NCHS, National Vital Statistics System, Mortality File, 2015, last accessed Dec. 11, 2015.

6 Paulozzi et al analyzed mortality figures and found that of 38,329 drug overdose deaths then reported in 2010, pharmaceutical drugs accounted for 22,134 deaths, of which 16,651 were opiod analgesic overdoses. The data were apparently revised slightly between the time the research letter was published in JAMA (February 2013) and release of the CDC's Deaths: Final Data for 2010 publication report, officially dated May 8, 2013.
7 Hedegaard H, Warner M, Miniño AM. Drug overdose deaths in the United States, 1999–2016. NCHS Data Brief, no 294. Hyattsville, MD: National Center for Health Statistics. 2017.

Source: 

Murphy SL, Xu JQ, Kochanek KD, Curtin SC, Arias E. Deaths: Final data for 2015. National Vital Statistics Reports; vol 66 no 6. Hyattsville, MD: National Center for Health Statistics. 2017.
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Hedegaard H, Chen LH, Warner M. Drug poisoning deaths involving heroin: United States, 2000–2013. NCHS data brief, no 190. Hyattsville, MD: National Center for Health Statistics. 2015.
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Chen LH, Hedegaard H, Warner M. Drug-poisoning deaths involving opioid analgesics: United States, 1999–2011. NCHS data brief no. 166.
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Christopher M. Jones, PharmD, Karin A. Mack, PhD, and Leonard J. Paulozzi, MD, "Pharmaceutical Overdose Deaths, United States, 2010," Journal of the American Medical Association, February 20, 2013, Vol 309, No. 7, p. 658.
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U.S. Department of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014. Printed with corrections, January 2014, p. 660, Table 12.4
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